Drug Delivery Systems

摘要: To obtain a given therapeutic response, the suitable amount of active drug must be absorbed and transported to site action at right time rate input can then adjusted produce concentrations required maintain level effect for as long necessary. The distribution tissues other than sites organs elimination is unnecessary, wasteful, potential cause toxicity. modification means delivering by projecting preparing new advanced delivery devices improve therapy. aim control (1) release from formulations or dosage forms, (2) reach absorbing membranes surfaces, (3) site-specific release. body are two most important features various devices. were taken into consideration their usefull successful applications in disease therapy discussed. In particular, attention was focused on use microelectro-mechanical-systems, cyclodextrins (the representative molecular systems), microemulsion organogel (supramolecular aggregates), colloidal carriers (liposomes, niosomes, ethosomes, ultradeformable vesicles, nanoparticles) drugs. Keywords: microelectro-mechanical systems; drug systems; controlled release; targeting; liposomes; nanoparticles; microemulsions; cyclodextrins