Wound healing in normal and analbuminemic (NAR) rats.
作者： Andrew Felcher , Jonathan Schwartz , Chaim Shechter , Stanley M. Levenson , Achilles A. Demetriou
DOI: 10.1016/0022-4804(87)90129-6
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摘要: Abstract It has been suggested by several investigators that hypoalbuminemia results in impaired wound healing. In most studies, however, is a manifestation of malnutrition or underlying liver disease. this study, we examined the effect isolated on Analbuminemic (NAR) rats which are Sprague-Dawley mutants with trace levels plasma albumin due to defect synthesis were studied. Adult NAR and (n = 10 each) underwent 7 cm dorsal skin incision implantation polyvinyl alcohol sponge subcutaneously under pentobarbital anesthesia. Seven days postoperatively all killed ether, wounds excised, breaking strength was measured. Sponge hydroxyproline content determined colorimetrically. There no significant differences (fresh formalin fixed) collagen between analbuminemic rats. We conclude detrimental healing
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