Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats.
作者： Carlos Henrique Rocha Catalão , Anderson Oliveira Souza , Nilton Nascimento Santos-Júnior , Stephanya Covas da Silva , Luís Henrique Angenendt da Costa
DOI: 10.1016/J.BRAINRES.2019.146408
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摘要: Abstract In hydrocephalus, the progressive accumulation of cerebrospinal fluid (CSF) causes dilatation lateral ventricles affecting third ventricle and diencephalic structures such as hypothalamus. These play a key role in regulation several neurovegetative functions by production hormones. Since endocrine disturbances are commonly observed hydrocephalic children, we investigated impact ventricular dilation on hypothalamus infant rats submitted to kaolin-induced hydrocephalus. Seven-day-old were hydrocephalus induction kaolin 20% injection method. After 14 days, animals decapitated brain was collected analyze mitochondrial function, neuronal activity acetylcholinesterase (AChE) enzyme, oxidative damage, glial activation, and, neurotransmission-related proteins anti-apoptotic processes The showed reduction respiratory rates States phosphorylation (P
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