Pre- and postshunting magnetization transfer ratios are in accordance with neurological and behavioral changes in hydrocephalic immature rats.

摘要: Hydrocephalus is a common neurological condition in children characterized by an imbalance between the production and absorption of cerebrospinal fluid (CSF), causing abnormal accumulation brain cavities. Shunt systems have been used to drain excess CSF prevent progressive ventricular enlargement. However, despite improvements these systems, structural changes cannot always be reversed. Our aim was evaluate magnetization transfer ratio as biomarker for effectiveness shunt system treat behavioral disorders observed experimental hydrocephalus. Seven-day-old Wistar rats were this study. The pups subjected hydrocephalus induction via 20% kaolin intracisternal injection. After confirmation ventriculomegaly magnetic resonance imaging (MRI), group animals underwent placement ventriculosubcutaneous (VSS). reduction size hydrocephalic operated with functional VSS decrease values preservation corpus callosum thickness. Magnetization significantly increased matched recovery process axonal myelination based on more-intense blue staining solochrome cyanin. histopathological analysis revealed reactive astrocytes means GFAP immunostaining. also showed significant progress motor exploratory activities, similar control animals, at end experiment. In conclusion, employed 7 days after able damage restore periventricular structures stabilizing reducing enlargement, results are accordance MRI.