Dynamic changes in cerebral blood flow and angiogenesis after transient focal cerebral ischemia in rats. Evaluation with serial magnetic resonance imaging.
作者： Teng-Nan Lin , Shu-Wei Sun , Wai-Mui Cheung , Fuhai Li , Chen Chang
DOI: 10.1161/01.STR.0000037675.97888.9D
关键词:
摘要: Background and Purpose— Angiogenesis occurs after cerebral ischemia, but the relationship between angiogenesis hemodynamic change is unknown. The aim of present study was to investigate ischemia-induced hemodynamics in a well-defined 3-vessel occlusion model rat by using diffusion- (DWI), perfusion-, T2-weighted MRI (T2WI). Methods— Rats were subjected 60 minutes transient middle artery or sham operation. DWI T2WI used characterize extent ischemic lesion from 4.5 hours 14 days reperfusion. A flow-sensitive alternating inversion recovery method dynamic susceptibility contrast evaluate temporal changes relative blood flow (CBF) volume (CBV), respectively. randomly selected killed at each time point for investigation vascular density hematoxylin-eosin staining. Results— Ischemic lesions developed ...
sci-hub.se 参考文章(42)
Peter Carmeliet, Mechanisms of angiogenesis and arteriogenesis. Nature Medicine. ,vol. 6, pp. 389- 395 ,(2000) , 10.1038/74651
Werner Risau, Mechanisms of angiogenesis Nature. ,vol. 386, pp. 671- 674 ,(1997) , 10.1038/386671A0
Teng N Lin, Jeannie Te, Melody Lee, Grace Y Sun, Chung Y Hsu, Induction of basic fibroblast growth factor (bFGF) expression following focal cerebral ischemia Molecular Brain Research. ,vol. 49, pp. 255- 265 ,(1997) , 10.1016/S0169-328X(97)00152-6
Takeshi Hayashi, Koji Abe, Yasuto Itoyama, Reduction of ischemic damage by application of vascular endothelial growth factor in rat brain after transient ischemia Journal of Cerebral Blood Flow and Metabolism. ,vol. 18, pp. 887- 895 ,(1998) , 10.1097/00004647-199808000-00009
T. Chyi, C. Chang, Temporal evolution of 3-nitropropionic acid-induced neurodegeneration in the rat brain by T2-weighted, diffusion-weighted, and perfusion magnetic resonance imaging. Neuroscience. ,vol. 92, pp. 1035- 1041 ,(1999) , 10.1016/S0306-4522(99)00076-7
Teng-Nan Lin, Gau-Ming Nian, Shu-Fen Chen, Wai-Mui Cheung, Chen Chang, Wen-Chang Lin, Chung Y. Hsu, Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion. Journal of Cerebral Blood Flow and Metabolism. ,vol. 21, pp. 690- 701 ,(2001) , 10.1097/00004647-200106000-00007
T. Kawamata, W. D. Dietrich, T. Schallert, J. E. Gotts, R. R. Cocke, L. I. Benowitz, S. P. Finklestein, Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following focal cerebral infarction Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 8179- 8184 ,(1997) , 10.1073/PNAS.94.15.8179
Laszlo Olah, Stefan Wecker, Mathias Hoehn, None, Secondary deterioration of apparent diffusion coefficient after 1-hour transient focal cerebral ischemia in rats Journal of Cerebral Blood Flow and Metabolism. ,vol. 20, pp. 1474- 1482 ,(2000) , 10.1097/00004647-200010000-00009
Judah Folkman, Angiogenesis in cancer, vascular, rheumatoid and other disease Nature Medicine. ,vol. 1, pp. 27- 31 ,(1995) , 10.1038/NM0195-27
F. Li, M. D. Silva, C. H. Sotak, M. Fisher, Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI. Neurology. ,vol. 54, pp. 689- 689 ,(2000) , 10.1212/WNL.54.3.689