A Factor in Lungs of Anaphylactically Shocked Guinea Pigs Which Can Induce Eosinophilia in Normal Animals

摘要: 1 . Absolute eosinophil counts of normal guinea pigs were obtained before, and twenty-four hours after, intraperitoneal implantation lung slices from sensitized pigs, other tissues—intestines, uterus, gall bladder, liver, skin—from which died in anaphylactic shock. Changes the number circulating eosinophils recipients also determined after transfer same donor animal before reinjection specific antigen, lungs shocked animals incubated at 56 C. for 40 minutes. 2. Transfer tissue (but not reinjected) into peritoneal cavity produces a significant, but limited, increase recipients. 3. shock marked transitory eosinophilia. 4. Removal one compared with antigen demonstrates that eosinotactic factor develops immediately shock. 5. intestines, liver (compared lung) small, recipient; skin limited experiments appears to depress peripheral count recipients. 6. donors 58 minutes less eosinophilia than kept room temperature period.