Fibroblast heterogeneity in glucocorticoid regulation of collagen metabolism: genetic or epigenetic?

摘要: Cultured fibroblasts derived from normal human dermis show a consistent 62% inhibition of collagen synthesis by hydrocortisone, whereas cultures keloids average only 30% and much larger strain to variation ranging 75% 49% stimulation. Examination fibroblast clones indicates that this high among keloid strains is not due differences in the proportion cells mass culture populations. Small but significant effect hydrocortisone on deposition are also seen these clonal populations, related type tissue which were derived. Two three-fold single individual observed, possibly suggesting functional heterogeneity dermal with regard metabolism under control conditions response hydrocortisone. However, may simply reflect growth, inasmuch as both deposition, processes, strongly affected population density.