Evaluation of Prognostic Impact of Soluble CD14 in B-Chronic Lymphocytic Leukemia
作者： Waiel Al-Kahiry , Homam Sharshira , Amal Ghanem , Maha El-gammal , Irene Lewis Mikhael
DOI: 10.1007/S12288-016-0745-0
关键词:
摘要: sCD14 is an acute phase reactant; few studies reported its prognostic value in B-CLL patients. This gave us the impetus to conduct this study. study enrolled 40 newly diagnosed Egyptian patients, presented Hematology Department of Medical Research Institute Alexandria University. The ZAP-70 was determined by flow cytometry whereas serum concentration human sandwich ELISA method. mean level significantly higher among patients with positive ZAP-70, Binet stage C, Rai III–IV and high risk CLL index. It showed a significant correlation percentage expression negative hemoglobin concentration. Serum could be used assess initially as additional marker, especially low resources areas where not available.
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Camille Chenevier-Gobeaux, Didier Borderie, Nicolas Weiss, Thomas Mallet-Coste, Yann-Erick Claessens, Presepsin (sCD14-ST), an innate immune response marker in sepsis Clinica Chimica Acta. ,vol. 450, pp. 97- 103 ,(2015) , 10.1016/J.CCA.2015.06.026
H. W. L. Ziegler-Heitbrock, Molecular Mechanism in Tolerance to Lipopolysaccharide Journal of Inflammation. ,vol. 45, pp. 13- 26 ,(1995)
R Thieringer, T B Morrison, J H Weis, J J Weis, R M Wooten, S D Wright, The role of CD14 in signaling mediated by outer membrane lipoproteins of Borrelia burgdorferi Journal of Immunology. ,vol. 160, pp. 5485- 5492 ,(1998)
R.I. Tapping, P.S. Tobias, Soluble CD14-mediated cellular responses to lipopolysaccharide. Chemical Immunology. ,vol. 74, pp. 108- 121 ,(2000) , 10.1159/000058751
Sylvette Bas, Benoit R. Gauthier, Ursula Spenato, Sybille Stingelin, Cem Gabay, CD14 Is an Acute-Phase Protein Journal of Immunology. ,vol. 172, pp. 4470- 4479 ,(2004) , 10.4049/JIMMUNOL.172.7.4470
Maria Grazia Malabarba, Dan L. Longo, Igor Espinoza-Delgado, Tammy K. Rowe, Luigi Varesio, Maria Caria Bosco, Functional role for the myeloid differentiation antigen CD14 in the activation of human monocytes by IL-2. Journal of Immunology. ,vol. 159, pp. 2922- 2931 ,(1997)
Martine E. D. Chamuleau, Theresia M. Westers, Arjan A. van de Loosdrecht, Annuska Strunk, Pino Poddighe, Andre P. Abbes, Tom G. H. Wiggers, Guus Westra, Ellen Kuiper-Kramer, ZAP70 in B-CLL cells related to the expression in NK cells is a surrogate marker for mutational status. Cytometry Part B-clinical Cytometry. ,vol. 86, pp. 280- 287 ,(2013) , 10.1002/CYTO.B.21132
Massimo Gentile, Francesca R. Mauro, Davide Rossi, Iolanda Vincelli, Giovanni Tripepi, Anna G. Recchia, Laura De Stefano, Melissa Campanelli, Diana Giannarelli, Sabrina Bossio, Lucio Morabito, Ernesto Vigna, Gianluca Gaidano, Robin Foà, Fortunato Morabito, Italian external and multicentric validation of the MD Anderson Cancer Center nomogram and prognostic index for chronic lymphocytic leukaemia patients: analysis of 1502 cases. British Journal of Haematology. ,vol. 167, pp. 224- 232 ,(2014) , 10.1111/BJH.13032
F. Caligaris-Cappio, Inflammation, the microenvironment and chronic lymphocytic leukemia Haematologica. ,vol. 96, pp. 353- 355 ,(2011) , 10.3324/HAEMATOL.2010.039446
K Egerer, E Feist, U Rohr, A Pruss, G-R Burmester, T Dörner, Increased serum soluble CD14, ICAM-1 and E-selectin correlate with disease activity and prognosis in systemic lupus erythematosus. Lupus. ,vol. 9, pp. 614- 621 ,(2000) , 10.1191/096120300678828749