Vitamin B6 treatment of gestational diabetes mellitus

作者: W.N. Spellacy , W.C. Buhi , S.A. Birk

DOI: 10.1016/0002-9378(77)90356-8

关键词:

摘要: Thirteen women with late pregnancy gestational diabetes mellitus were tested an intravenous glucose tolerance test and both blood plasma insulin levels measured. Each woman was then treated 100 mg. of vitamin B6 per day for 2 weeks the repeated. There a statistically significant improvement in curve after treatment, lowering at all points on except 5 minute value. This effect occurred despite unchanged or lowered level. These results suggest that relative deficiency is associated some cases replacement this improves metabolic state. The low appear to alter pathways which result biologic activity endogenous insulin.

参考文章(16)
John B. O'Sullivan, David Charles, Clare M. Mahan, Robert V. Dandrow, Gestational diabetes and perinatal mortality rate. American Journal of Obstetrics and Gynecology. ,vol. 116, pp. 901- 904 ,(1973) , 10.1016/S0002-9378(16)33834-0
E. C. AMOROSO, Endocrinology of pregnancy. British Medical Bulletin. ,vol. 11, pp. 117- 125 ,(1955) , 10.1093/OXFORDJOURNALS.BMB.A069463
Norton Nelson, A PHOTOMETRIC ADAPTATION OF THE SOMOGYI METHOD FOR THE DETERMINATION OF GLUCOSE Journal of Biological Chemistry. ,vol. 153, pp. 375- 380 ,(1944) , 10.1016/S0021-9258(18)71980-7
YAHITO KOTAKE, YOSHIKO SOTOKAWA, EDAHIKO MURAKAMI, AYAKO HISATAKE, MASAKAZU ABE, YOSHIO IKEDA, Physiological activities of xanthurenic acid-8-methyl ether-insulin complex. Journal of Biochemistry. ,vol. 64, pp. 895- 896 ,(1968) , 10.1093/OXFORDJOURNALS.JBCHEM.A128971
Edwin R. Zartman, Allan C. Barnes, Dorothy J. Hicks, Observations on pyridoxine metabolism in pregnancy. American Journal of Obstetrics and Gynecology. ,vol. 70, pp. 645- 649 ,(1955) , 10.1016/0002-9378(55)90360-4
Michael Somogyi, Determination of blood sugar. Journal of Biological Chemistry. ,vol. 160, pp. 69- 73 ,(1945) , 10.1016/S0021-9258(18)43098-0
Robert E. Cleary, Lawrence Lumeng, Ting-Kai Li, Maternal and fetal plasma levels of pyridoxal phosphate at term: adequacy of vitamin B6 supplementation during pregnancy. American Journal of Obstetrics and Gynecology. ,vol. 121, pp. 25- 28 ,(1975) , 10.1016/0002-9378(75)90968-0
FREDERICK C. GOETZ, BERYL Z. GREENBERG, JOYCE ELLS, CURTIS MEINERT, A SIMPLE IMMUNOASSAY FOR INSULIN: APPLICATION TO HUMAN AND DOG PLASMA. The Journal of Clinical Endocrinology and Metabolism. ,vol. 23, pp. 1237- 1246 ,(1963) , 10.1210/JCEM-23-12-1237
VICTOR HERBERT, KAM-SENG LAU, CHESTER W. GOTTLIEB, SHELDON J. BLEICHER, Coated charcoal immunoassay of insulin. The Journal of Clinical Endocrinology and Metabolism. ,vol. 25, pp. 1375- 1384 ,(1965) , 10.1210/JCEM-25-10-1375