Usefulness of a rapid initial increase in plasma creatine kinase activity as a marker of reperfusion during thrombolytic therapy for acute myocardial infarction

摘要: This study evaluates a new nonangiographic marker of reperfusion--a rapid initial increase in plasma creatine kinase (CK) and CK-MB activity--in 50 patients receiving intracoronary streptokinase. Blood for CK activity was sampled at 30-minute intervals angiography performed 15-minute or earlier if there were clinical signs suggestive reperfusion. An absolute first-hour 480 +/- 345 IU/liter (range 54 to 1,440 IU/liter), relative 34 18% 13 67% the peak rise), an 48 36 10 144 IU/liter) 27 13% 57%) found immediately after reperfusion with Thrombolysis In Myocardial Infarction (TIMI) grade 3 perfusion artery infarction. The onset closely reflected time angiographic documentation contrast, absence reperfusion, rate measured last hour 2 1/2-hour period beginning start treatment only 15 9 on average 30 rise 2% 1 6%).(ABSTRACT TRUNCATED AT 250 WORDS)