Hepatoprotective activity of aqueous methanolic extract of Morus nigra against paracetamol-induced hepatotoxicity in mice

摘要: Morus nigra (Family Moraceae) is traditionally used injaundice, diabetes, hypertension, cough, fever and cancer. The current study was conducted to determine hepatoprotective activity of aqueous methanolic extract leaves M. . Two doses 250 mg/kg p.o 500 showed that produced significant (p<0.001) reduction in liver enzymes (ALT, AST, ALP) total bilirubin induced by paracetamol the results are comparable silymarin (p<0.001). Results were supported histopathologi-cal investigations, phytochemical screening detection active consti-tuents HPLC. possess might be due quercetin, luteolin isorhamnetin. It concluded from this has against injury mice. DOI: http://dx.doi.org/10.3329/bjp.v9i1.17337 Bangladesh J Pharmacol 2014; 9: 60-66