Epigenetic therapy for cancer

摘要: Epigenetics means the study of alterations in genetic material that affect phenotype but does not genotype. cause cell properties, which are inherited; it DNA sequence. Epigenetic mediated silencing gene is four types, methylation, histone deacetylation, RNA associated and Genomic imprinting. Other factors (environmental xenobiotics) can also methytlation changes histones chromatin two important changes, responsible for malignant diseases. Two groups drugs under development, corrects epigenetic alterations. These deacetylation (HDAC) inhibitors methytransferase (DNMT) inhibitors. may be used cancer because cancer, hypermethylation suppressor causes silencing. therapy scope likely to increase future.