Regulation of human interleukin 8 gene expression and binding of several other members of the intercrine family to receptors for interleukin-8.

摘要: Recruitment of leukocytes into tissues presumeably involves the local release leukocyte activating and chemotactic mediators in response to injury-induced inflammatory reactions. We have recently purified major neutrophil, monocyte, lymphocyte factors homogeneity from conditioned media human PBMC or monocytic cell line stimulated with mitogens shown that these are structurally distinct known cytokines, including IL-1 TNF (1,2,3). Neutrophil factor was identical T has been renamed IL-8 (3). is monocyte (MCAF) (2). cDNA cloning performed encodes a 99 amino acid precursor form (4). There typical signal peptide at terminal end molecule mature processed soluble extracellular consists 72 acids. shows considerable sequence homology several such as β-thromboglobulin, platelet 4, gamma-IP 10 GRO/MGSA. For ease communication we will identify cytokines members intercrine family this article. Such generic term may provide useful providing name for cytokine based on their chromosomal location when they precisely determined over next few years. example, located chromosome 4 can therefore be assigned number α subfamily, whereas MCAF others 17 β subfamily.