Two-stage extraction of antitumor, antioxidant and antiacetylcholinesterase compounds from Ganoderma lucidum fruiting body

作者: Urška Batista , Andrej Gregori , Franc Pohleven , Tonica Bončina , Darija Cör

DOI: 10.1016/J.SUPFLU.2014.04.006

关键词:

摘要: Abstract Ganoderma lucidum has been used in oriental medicine for its contribution to vitality and longevity. None of them report about targeted antitumor activity against adenocarcinoma cells, or antioxidant antiacetylcholinesterase potential application treatment Alzheimer's other neurodegenerative diseases. To date, there are a few studies available concerning supercritical carbon dioxide extraction biologically active compounds from G. fruiting body. In our study, two stage extractions were performed. First, was as solvent. Next, the same material hot water isolation polysaccharides. Cytotoxicity, tested all obtained extracts. Additionally, effect process conditions on biological extracts assessed.

参考文章(26)
A. V. Avtonomova, L. M. Krasnopol’skaya, V. N. Maksimov, Optimization of nutrient medium for submerged cultivation of Ganoderma lucidum (Curt.: Fr.) P. Karst Microbiology. ,vol. 75, pp. 148- 153 ,(2006) , 10.1134/S002626170602007X
Michel. DuBois, K. A. Gilles, J. K. Hamilton, P. A. Rebers, Fred. Smith, Colorimetric Method for Determination of Sugars and Related Substances Analytical Chemistry. ,vol. 28, pp. 350- 356 ,(1956) , 10.1021/AC60111A017
George L. Ellman, K.Diane Courtney, Valentino Andres, Robert M. Featherstone, A new and rapid colorimetric determination of acetylcholinesterase activity Biochemical Pharmacology. ,vol. 7, pp. 88- 95 ,(1961) , 10.1016/0006-2952(61)90145-9
Sandrina A. Heleno, Lillian Barros, Anabela Martins, Maria João R.P. Queiroz, Celestino Santos-Buelga, Isabel C.F.R. Ferreira, Fruiting body, spores and in vitro produced mycelium of ganoderma lucidum from northeast Portugal : a comparative study of the antioxidant potential of phenolic and polysaccharidic extracts Food Research International. ,vol. 46, pp. 135- 140 ,(2012) , 10.1016/J.FOODRES.2011.12.009
Ti-qiang Chen, Jian-guo Wu, Yan-bin Wu, Hong-yu Wang, Fang-hua Mao, Jin-zhong Wu, Supercritical fluid CO2 extraction, simultaneous determination of total sterols in the spore lipids of Ganoderma lucidum by GC-MS/SIM methods Chemistry of Natural Compounds. ,vol. 48, pp. 657- 658 ,(2012) , 10.1007/S10600-012-0338-6
HUI-YIN FU, DEN-EN SHIEH, CHI-TANG HO, ANTIOXIDANT AND FREE RADICAL SCAVENGING ACTIVITIES OF EDIBLE MUSHROOMS Journal of Food Lipids. ,vol. 9, pp. 35- 43 ,(2002) , 10.1111/J.1745-4522.2002.TB00206.X
Majda Hadolin, Mojca S̆kerget, Z̆eljko Knez, Davorin Bauman, HIGH PRESSURE EXTRACTION OF VITAMIN E-RICH OIL FROM SILYBUM MARIANUM Food Chemistry. ,vol. 74, pp. 355- 364 ,(2001) , 10.1016/S0308-8146(01)00152-2
Sahar El-Mekkawy, Meselhy R Meselhy, Norio Nakamura, Yasuhiro Tezuka, Masao Hattori, Nobuko Kakiuchi, Kunitada Shimotohno, Takuya Kawahata, Toru Otake, None, Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma Lucidum Phytochemistry. ,vol. 49, pp. 1651- 1657 ,(1998) , 10.1016/S0031-9422(98)00254-4