In vitro pigment formation from tryptamine. Role of indole-3-acetaldehyde.
作者： P.K. Das , S.R. Guha
DOI: 10.1016/0006-2952(85)90564-7
关键词:
摘要: The metabolic significance of indole-3-acetaldehyde in the process vitro pigment formation from tryptamine presence guinea-pig liver mitochondria was investigated. Among four type selective MAO inhibitors used, pargyline and deprenyl appear to be more effective inhibiting than serotonin, while clorgyline Lilly 51641, serotonin preferentially inhibited. Reducing agents like ascorbic acid, cysteine glutathione were found block significantly. Also, a reduction noted NADH ethanol but not NAD. It observed that amount produced enzymatically under present experimental conditions is sufficient account for total formed standard incubation mixture generation nascent aldehyde has greater contribution supplemented system exogenously. appears indole-3-acetaldehyde, are associated with formation.
elsevier.com
sci-hub.se 参考文章(22)
Caecilia Elisabeth Mary Pugh, Juda Hirsch Quastel, Oxidation of amines by animal tissues. Biochemical Journal. ,vol. 31, pp. 2306- 2321 ,(1937) , 10.1042/BJ0312306
Sidney Udenfriend, Elwood Titus, Herbert Weissbach, Ralph E. Peterson, BIOGENESIS AND METABOLISM OF 5-HYDROXYINDOLE COMPOUNDS Journal of Biological Chemistry. ,vol. 219, pp. 335- 344 ,(1956) , 10.1016/S0021-9258(18)65798-9
Walter C. Schneider, George H. Hogeboom, INTRACELLULAR DISTRIBUTION OF ENZYMES V. FURTHER STUDIES ON THE DISTRIBUTION OF CYTOCHROME c IN RAT LIVER HOMOGENATES Journal of Biological Chemistry. ,vol. 183, pp. 123- 128 ,(1950) , 10.1016/S0021-9258(18)56449-8
Hara P. Misra, Irwin Fridovich, The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase Journal of Biological Chemistry. ,vol. 247, pp. 3170- 3175 ,(1972) , 10.1016/S0021-9258(19)45228-9
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Herbert Sprince, Indole Metabolism in Mental Illness Clinical Chemistry. ,vol. 7, pp. 203- 230 ,(1961) , 10.1093/CLINCHEM/7.3.203
Bendicht Wermuth, Jacqueline D.B. Mu¨nch, Reduction of biogenic aldehydes by aldehyde reductase and alcohol dehydrogenase from human liver. Biochemical Pharmacology. ,vol. 28, pp. 1431- 1433 ,(1979) , 10.1016/0006-2952(79)90449-0
N.H. Neff, H.-Y.T. Yang, Another look at the monoamine oxidases and the monoamine oxidase inhibitor drugs Life Sciences. ,vol. 14, pp. 2061- 2074 ,(1974) , 10.1016/0024-3205(74)90089-7
W. Bors, M. Saran, C. Michel, E. Lengfelder, C. Fuchs, R. Spöttl, Pulse-radiolytic investigations of catechols and catecholamines. I. Adrenaline and adrenochrome. International Journal of Radiation Biology. ,vol. 28, pp. 353- 371 ,(1975) , 10.1080/09553007514551141
P.K. Das, S.R. Guha, MAO types in guinea pig liver mitochondria Biochemical Pharmacology. ,vol. 29, pp. 2049- 2053 ,(1980) , 10.1016/0006-2952(80)90490-6