Prediction of anaphylaxis during peanut food challenge: usefulness of the peanut skin prick test (SPT) and specific IgE level.

摘要: Cutoffs (decision points) of the peanut skin prick test (SPT) and specific IgE level for predicting allergy have been proposed. It is not known whether decision points indicating a significant risk severe reactions on challenge differ from those probable allergy. We aimed at determining usefulness tests anaphylaxis following ingestion up to 12 g in peanut-sensitized children. Children attending Allergy Clinic who had positive SPT completed open-label in-hospital challenges were included. The protocol provided be continued beyond initial mild reactions. Eighty-nine performed. Thirty-four excluded as was completed, leaving 55 analysis. did react (n = 28) or reacted without 6) represented comparison group 34). study comprised 21 children whose resulted anaphylaxis. mean wheal size associated with severity challenge. Among children, developed anaphylaxis, only 3 cases reaction. Unexpectedly, history predictive Anaphylaxis cumulative doses ranging 0.02 11.7 g. Provided that fixed amount ingested, available may assist during