The association of the insulin resistance syndrome with impaired glucose tolerance and NIDDM in the Japanese general population: the Hisayama study.

摘要: To elucidate the risk factors for initiating glucose intolerance, relevant were explored in a cross-sectional survey conducted sample population aged 40–79 years old selected from Japanese community, Hisayama, Japan 1988. A 75-g oral tolerance test was used to classify 1,073 men (72.5% of entire same age range) and 1,407 women (80.5%) into normal, impaired diabetes mellitus groups. In all sex groups with normal tolerance, sum fasting 2-h post-load insulin values varied widely demonstrated significant positive correlations triglycerides, body mass index, waist-hip ratio, systolic diastolic blood pressure, while it negatively correlated HDL cholesterol (p<0.05). Insulin resistance presumed develop subjects hyperinsulinaemia. The concentrations, ratio pressure levels significantly associated after adjustment (p<0.05) also related either or some groups, respectively It shown that intolerance general resistance. These data, therefore, support hypothesis is primary defect development population. However, further prospective study still needed order confirm this hypothesis.