Characterization and in vitro activity of a branched peptide boronic acid that interacts with HIV-1 RRE RNA.
作者： Jessica E. Wynn , Wenyu Zhang , Denis M. Tebit , Laurie R. Gray , Marie-Louise Hammarskjold
DOI: 10.1016/J.BMC.2016.04.009
关键词:
摘要: Abstract A branched peptide containing multiple boronic acids was found to bind RRE IIB selectively and inhibit HIV-1 p24 capsid production in a dose-dependent manner. Structure–activity relationship studies revealed that branching the is crucial for low micromolar binding towards IIB, demonstrates selectivity presence of tRNA. Footprinting suggest site on upper stem internal loop regions RNA, which induces enzymatic cleavage loops upon binding.
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