Factors affecting pharmacokinetics of benzimidazole anthelmintics in food-producing animals: the consequences and potential risks.

摘要: Benzimidazoles are frequently and widely used veterinary anthelmintics. Unfortunately, an administration of these anthelmintics does not always result in the expected therapeutic success. Many host-related factors modify pharmacokinetic behavior efficacy a chosen anthelmintic. Pharmacokinetics varies among animals different species, sex age. Also diseases, medication, feed environmental conditions can significantly affect resultant drug animals. The presented review gathers information, gained last 20 years, on which bring about variability performance benzimidazole food-producing It is focused particularly differences absorption metabolism as stages process seem to be most important for overall anthelmintic efficacy. consequences abnormalities alterations pharmacokinetics summarized discussed.