Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis.

摘要: The current therapeutic strategy for disseminated intravascular coagulation (DIC) is limited to control of the underlying disease, and methods effective management DIC have not been established. We report successful use tranexamic acid (TA) combined with unfractionated heparin in a patient life-threatening bleeding from sigmoid colon caused by DIC. A 35-year-old man who had undergone allogeneic bone marrow transplantation chronic myelogenous leukemia was referred relapse his leukemia. first treated imatinib at 600 mg/day. Although disappearance leukemic cells decrease BCR/ABL fusion gene were observed, he developed massive after defecation. laboratory diagnosis prominent fibrinolysis based on elevated levels both plasmin-alpha2-plasmin inhibitor complex thrombin-antithrombin III complex. Despite vigorous supportive therapy, including multiple transfusions aggressive fluid resuscitation, hypovolemic shock due uncontrollable bleeding. TA instituted inhibit excessive fibrinolysis. prompt response observed soon commencement therapy. No organ dysfunction throughout use. To our knowledge, this describe treatment intestinal acute associated hematologic malignancy.