Specific Killing Effect of 10B1-Para-boronophenylalanine in Thermal Neutron Capture Therapy of Malignant Melanoma: In Vitro Radiobiological Evaluation
作者： Masamitsu Ichihashi , Takafumi Nakanishi , Yutaka Mishima
DOI: 10.1111/1523-1747.EP12506489
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摘要: A 10 B-dopa analogue, B 1 -para-boronophenylalanine ( -BPA) has been found to have a marked melanoma killing effect as expressed by the Do value, 0.9−1.2 × 12 n/cm 2 . The value of neutron alone is 2.8 After introduction high LET irradiation into radiotherapy, its higher energy deposition in target cancer cells one major problems currently be solved. This can achieved our thermal capture therapy order cellular dimensions when we highly tumor-seeking B-compounds available. Our present evidence seems indicate that new -BPA concentrate cells, much 11 times level medium vitro system.
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