Cytogenetic abnormalities in adult non-promyelocytic acute myeloid leukemia: A concise review

作者: Francesco Marchesi , Ombretta Annibali , Elisabetta Cerchiara , Maria Cristina Tirindelli , Giuseppe Avvisati

DOI: 10.1016/J.CRITREVONC.2010.11.006

关键词:

摘要: Abstract Cytogenetic abnormalities are found in 50–60% of newly diagnosed acute myeloid leukemia (AML) adult patients. analysis bone marrow leukemic cells is an important pre-treatment evaluation for a correct prognostic stratification patients, that permit to separate AML patients three broad categories: high, intermediate and low risk. The determination cytogenetic features remains corner stone predicting outcome although today its use needs be integrated by molecular immunophenotypic data, particularly cytogenetically normal (CN) group In this review we perform concise description more recurrent aberrations AML, theirs correlations with biological clinical data strong impact useful therapeutic decision.

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