Acute myeloid leukemia with t(6;9) (p23;q34): association with myelodysplasia, basophilia, and initial CD34 negative immunophenotype.

摘要: The translocation (6;9)(p23;q34) is a rare cytogenetic aberration found in patients with acute myeloid leukemia (AML). clinical, morphologic, and immunophenotypic findings of eight t(6;9) leukemias are described. included six men two women mean age 38.5 years. were classified the French-American-British (FAB) system as AML FAB M2 four cases M4 cases. Underlying myelodysplasia was evident Bone marrow basophilia at presentation seven studied. In basophilia, darkly stained granules also present many eosinophils. one case, initial absent, but relapse, eosinophils containing granules. Iron stains available five cases; showed increased incorporation three had ringed sideroblasts. All studied by flow cytometry (six relapse) expressed CD13, CD33, human leukocyte antigen-DR. At presentation, CD34 negative. case subset blasts (18%) weakly CD34. Three relapse positive for Two terminal deoxynucleotidyl transferase positive. t(6;9)(p23;q34) only abnormality Trisomy 8 cases, ring 12 case. living refractory 6 weeks to months after diagnosis, died complications allogeneic bone transplantation. Only patient alive without evidence disease 3 years an unusual type that associated poor prognosis, early onset, frequent sideroblasts, CD34-negative phenotype.