The role of FLT3 in haematopoietic malignancies

摘要: Normal haematopoietic cells use complex systems to control proliferation, differentiation and cell death. The of proliferation is, in part, accomplished through the ligand-induced stimulation receptor tyrosine kinases, which signal downstream effectors RAS pathway. Recently, mutations FMS-like kinase 3 (FLT3) gene, encodes a kinase, have been found be most common genetic lesion acute myeloid leukaemia (AML), occurring approximately 25% cases. Exploring mechanism by these FLT3 cause uncontrolled might lead better understanding how become cancerous provide insights for development new drugs.