Hematopoietic receptors of class III receptor-type tyrosine kinases.

摘要: Receptor-type tyrosine kinases (RTKs) constitute a family of proteins involved in growth and developmental processes. Class III RTKs are characterized by an extracellular region composed five immunoglobulin-like domains split kinase domain. Some the class perform major functions hematopoiesis focus this review. They colony-stimulating factor-1 (CSF1) Steel factor (SLF) receptors, encoded FMS KIT protooncogenes, respectively, product FLT3/FLK2 gene. The structural, biochemical, functional, pathological features these three receptors genes reviewed.