Soluble phosphorylated fms-like tyrosine kinase III. FLT3 protein in patients with acute myeloid leukemia (AML).

摘要: FLT3 ligand (FL) has a significant role in the proliferation and differentiation of hematopoietic cells. Mutations receptor gene have been reported 30% patients with AML. We investigated whether abnormal phosphorylation may be more common evaluated protein its plasma from 85 AML, 16 myelodysplastic syndrome (MDS) 5 acute lymphoblastic leukemia (ALL). There were no differences level different diseases (p = 0.57). AML had significantly higher phospho-FLT3:FLT3 ratio 0.02). FLT3-ITD point mutations present 27 (32%) patients. Phosphorylated was mutation 0.002). Overall, there correlation between survival or phosphorylated form. However, amongst without mutations, those shorter duration remission 0.04). Other mechanisms responsible for inhibitors should also mutations.