Regulation of Dendritic Cell Development by STATs

摘要: Dendritic cells (DCs) serve as a critical link between the innate and adaptive immune responses due to their ability sense pathogens respond by activating cell types. Delineating molecular control of DC development will provide important information about generation natural immunity well approaches regulate DCs in clinical settings. are generated from hematopoietic stem through specialized progenitor subsets response cytokine transcriptional cues, with FMS-like tyrosine kinase 3 ligand (Flt3L) Flt3L receptor (Flt3) signaling providing major pathway supporting homeostatic generation. Recent work has indicated that granulocyte-macrophage colony-stimulating factor (GM-CSF) type I interferons (IFNs) also play roles regulating subset production. Here we review new insight into mechanisms which cytokine-activated STAT proteins developmental process.