作者: Sidney Pestka
DOI: 10.1002/1097-0282(2000)55:4<254::AID-BIP1001>3.0.CO;2-1
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摘要: Interferon (IFN) was approved by the U.S. Food and Drug Administration on June 5, 1986. As first biotherapeutic approved, IFN-α paved way for development of many other cytokines growth factors. Nevertheless, we have just touched surface understanding multitude human IFNs. This paper reviews history purification leukocyte IFN key aspects our current state knowledge interferon α genes, proteins, receptors. © 2001 John Wiley & Sons, Inc. Biopolymers (Pept Sci) 55: 254–287, 2000