miRNome profiling of clonal stem cells in Ph+ CML
作者： María Sol Ruiz , María Belén Sánchez , Simone Bonecker , Carolina Furtado , Daniel Koile
DOI: 10.1101/2020.03.16.989194
关键词:
摘要: Chronic myeloid leukemia (CML) is a stem cell neoplasm characterized by an expansion of progenitor cells and the presence BCR-ABL1 oncoprotein. Since introduction specific tyrosine kinase inhibitors (TKI), overall survival has improved significantly. However, under long-term therapy patients may have residual disease that originates from TKI-resistant leukemic (LSC). In this work, we analyzed miRNome CML LSC, normal hematopoietic (HSC) obtained same patients, healthy donors (HD) next-generation sequencing. We detected global decrease microRNA levels in LSC HSC decreased microRNAs snoRNAs imprinted genomic cluster chromosome 14, suggesting mechanism silencing multiple non-coding RNAs. Surprisingly, despite absence expression, showed altered miRNome. silico analysis revealed association between validated metabolic pathways, these molecules be mediators previously reported dysregulation metabolism. This first report distinguishes BCR-ABL1+ vs. their BCR-ABL1- counterparts, providing valuable data for future studies.
sci-hub.st 参考文章(48)
Ioannis S. Vlachos, Konstantinos Zagganas, Maria D. Paraskevopoulou, Georgios Georgakilas, Dimitra Karagkouni, Thanasis Vergoulis, Theodore Dalamagas, Artemis G. Hatzigeorgiou, DIANA-miRPath v3.0: deciphering microRNA function with experimental support Nucleic Acids Research. ,vol. 43, ,(2015) , 10.1093/NAR/GKV403
A Chase, W Leung, W Tapper, A V Jones, L Knoops, C Rasi, L A Forsberg, P Guglielmelli, K Zoi, V Hall, L Chiecchio, L Eder-Azanza, C Bryant, L Lannfelt, L Docherty, H E White, J Score, D J G Mackay, A M Vannucchi, J P Dumanski, N C P Cross, Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus Leukemia. ,vol. 29, pp. 2069- 2074 ,(2015) , 10.1038/LEU.2015.130
Farah A. Falix, Daniël C. Aronson, Wouter H. Lamers, Ingrid C. Gaemers, Possible roles of DLK1 in the Notch pathway during development and disease Biochimica et Biophysica Acta. ,vol. 1822, pp. 988- 995 ,(2012) , 10.1016/J.BBADIS.2012.02.003
Yoichi Sekita, Hirotaka Wagatsuma, Kenji Nakamura, Ryuichi Ono, Masayo Kagami, Noriko Wakisaka, Toshiaki Hino, Rika Suzuki-Migishima, Takashi Kohda, Atsuo Ogura, Tsutomu Ogata, Minesuke Yokoyama, Tomoko Kaneko-Ishino, Fumitoshi Ishino, Role of retrotransposon-derived imprinted gene, Rtl1 , in the feto-maternal interface of mouse placenta Nature Genetics. ,vol. 40, pp. 243- 248 ,(2008) , 10.1038/NG.2007.51
Joby L McKenzie, Olga I Gan, Monica Doedens, Jean C Y Wang, John E Dick, Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nature Immunology. ,vol. 7, pp. 1225- 1233 ,(2006) , 10.1038/NI1393
JANET D. ROWLEY, Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining. Nature. ,vol. 243, pp. 290- 293 ,(1973) , 10.1038/243290A0
George A. Calin, Carlo M. Croce, MicroRNA signatures in human cancers Nature Reviews Cancer. ,vol. 6, pp. 857- 866 ,(2006) , 10.1038/NRC1997
Evangelos Briasoulis, Leonidas Benetatos, Eleftheria Hatzimichael, Eric Londin, George Vartholomatos, Phillipe Loher, Isidore Rigoutsos, The microRNAs within the DLK1-DIO3 genomic region: involvement in disease pathogenesis Cellular and Molecular Life Sciences. ,vol. 70, pp. 795- 814 ,(2013) , 10.1007/S00018-012-1080-8
Carlo M. Croce, Causes and consequences of microRNA dysregulation in cancer Nature Reviews Genetics. ,vol. 10, pp. 704- 714 ,(2009) , 10.1038/NRG2634
Dominique Bonnet, John E. Dick, Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell Nature Medicine. ,vol. 3, pp. 730- 737 ,(1997) , 10.1038/NM0797-730