Glass microelectrode tip capacitance: its measurement and a method for its reduction.

摘要: The frequency response of input amplifiers used for measurement bioelectric signals from small cells is severely limited by the resistance and capacitance fine glass microelectrodes which are required these measurements. A significant improvement in can be realized employing technique neutralization. This neutralization, however, incomplete since: (1) bandwidth amplifier finite; (2) a fraction electrode isolated part cannot compensated. It therefore desirable to ensure that as low possible before method discussed measuring predicting distributed microelectrode described coating outside near tip with substance lower per unit length much 7-fold. significance improved this provides light recent advances intracellular single voltage clamp technique.