Comparison of in vitro and in vivo α/β ratios for prostate cancer

摘要: Parallel in vitro and vivo studies provide insight into the relationship between clinical response intrinsic cellular radiosensitivity may aid development of predictive assays. Compilations parameters from experiments can also be used to examine potential effectiveness alternative or new treatment plan designs until enough data become available directly estimate requisite parameters. In this work, survival for six prostate cancer cell lines (ten datasets total) have been extracted literature re-analysed using linear-quadratic (LQ) model. The paired bootstrap technique regression is compute 95% confidence intervals estimated LQ derived are then compared cancer. Estimates alpha range 0.09 0.35 Gy(-1) (all lines), alpha/beta ratio ranges 1.09 6.29 Gy lines). Point estimates repair half-time (PPC-1, TSU-Pr1, PC-3 DU-145 lines) 5.7 8.9 h (95% interval 0.26 10.7 h). Differences determined reported by different laboratories as large larger than differences observed among various lines. demonstrate that even seemingly small corrections dose rate effects, such those expected high (HDR) experiments, sometimes a significant impact on alpha/beta. By neglecting effects analysis HDR alpha/beta, too factors 1.3 6.2. appears significantly (slower rate) data. However, approximately same vivo. Most consistent with an less 3 4 Gy.