Negative pressure wound therapy for surgical site infections: a systematic review and meta-analysis of randomized controlled trials

摘要: Abstract Objectives Previous studies showed the effectiveness of negative pressure wound therapy (NPWT) in preventing surgical site infections (SSIs), but current guidelines do not recommend its routine use for wounds. The aim was to compare and safety NPWT with standard dressing or conventional SSIs. Methods Pubmed, Embase Cochrane Library were systematically searched on 10 April 2019. Also, we clinicaltrials.gov references relevant studies. Eligibility criteria randomized controlled trials (RCTs) adult patients included. versus investigated. Relative risks (RRs) mean differences (MDs) 95% confidence intervals (CIs) used estimate pooled effect dichotomous outcomes continuous respectively. primary outcome infections. quality included certainty evidence assessed using risk bias tool GRADE approach. Results A total 45 RCTs 6624 reduced SSIs (RR 0.58; CI 0.49–0.69) dehiscence(17 RCTs; RR 0.80; 0.65–1.00). did increase hematoma (9 0.91; 0.40–2.07) hospital readmission(9 0.77; 0.52–1.12) prolong length stay(15 MD –0.38; CI, –0.78 0.02). significantly increased all adverse event-related (10 3.21; 1.17–8.78). level identified as low very secondary outcomes. Conclusions Compared care, may reduce We are uncertain whether reduces increases dehiscence, haematoma, readmission if it shortens prolongs stay.