Respective potencies of Botox and Dysport: a double blind, randomised, crossover study in cervical dystonia.

摘要: Objectives: Botulinum toxin type A is a potent neuromuscular paralyzing agent used in various disorders including cervical dystonia. Two preparations of botulinum are now commercially available ( Dysport and Botox), but much controversy remains about their respective potencies. The aim the study was to compare efficacy Botox with two different ratios Dysport. Methods: double blind, randomised, three period cross over involving 54 patients dystonia performed. received following treatments randomised order: at usually effective dose, dose 1:3 (conversion factor 3 between units—that is, one unit=three units) 1:4 four). improvement Tsui (primary outcome criteria) TWSTRS pain scales baseline control visit 1 month after each injections, as well incidence adverse events, were assessed. Results: Comparison scores showed better effect on impairment (p=0.02 0.04, respectively) (p=0.01 0.02, than Botox. number events higher both treatments. most frequent event dysphagia, found 3%, 15.6%, 17.3% (Botox, 1:4, patients. No required withdrawal therapy or specific management. Conclusions: (and greater extent) more efficient for although somewhat minor effects. This strongly suggests that appropriate conversion units less