In vivo genotoxicity assesment of silver nanoparticles of different sizes by the Somatic Mutation and Recombination Test (SMART) on Drosophila.

摘要: Abstract Silver nanoparticles (AgNPs) with antimicrobial activity are by far the most commercialized nano-compound. They commonly used in medical products and devices, food storage materials, cosmetics industrial products. Despite increasing human exposure to AgNPs, they remain a controversial research area regard their toxic genotoxic effects biological systems. Although previous data have suggested that AgNPs induce toxicity in vitro, in vivo studies on this topic very limited. In present study, potential of different sizes (4.7 42 nm) was evaluated using Somatic Mutation Recombination Test (SMART) Drosophila melanogaster. Larvae were treated 25, 30 50 μg/ml 4.7 nm, 250, 500 1000 μg/ml 42 nm. Data showed at applied concentrations did not modify spontaneous frequencies spots indicating lack mutagenic recombinogenic activity. However, both induced pigmentation defects reduction locomotor ability adult flies. Therefore, further experiments must be carried out gain better understanding mechanism action ensure safe use.