The effect of dihydroxy bile acids on intestinal secretion, cyclic nucleotides, and Na+-K+-ATPase

摘要: The effects of dihydroxy bile acids on intestinal cyclic nucleotides, Na+- K+-ATPase, and net secretion, propranolol pretreatment these actions were determined. Ileal colonic loops constructed in each 12 rabbits, six which treated with preoperatively. In random order, normal saline, 6mM deoxycholic, chenodeoxycholic, or ursodeoxycholic injected into the loops. Five hours later, luminal secretion mucosa! adenylate cyclase, phosphodiesterase, cGMP, Na+-K+-ATPase Deoxycholic chenodeoxycholic increased cyclase activity (<0.01) (p<0.01), decreased cGMP (p<0.05). Ursodeoxycholic acid did not alter but Phosphodiesterase unchanged. Propranolol reversed all effects. conclusion, deoxycholic induce probably via cAMP. does affect cAMP increases promote secretion.