Oncogenes and Mammary Carcinogenesis

摘要: Breast cancer is the most common malignancy among women in United States, accounting for nearly 32% ofall cancers and 20% deaths (1). a multifactorial disease, several factors are thought to influence risk of breast development, including geography, radiation exposure, reproductive family history. A history constitutes major factor, although familial accounts only 5% all cases Although declined by between 1989 1992 (2), incidence expected increase 2–3% annually (1), efforts decrease mortality significantly, new therapeutic approaches early diagnosis, have been relatively unsuccessful. One critical determining approach cancer, along with presence or absence lymph node metastasis, estrogen progesterone receptor (ER PR) status tumor. Indeed, ER- and/or PR-positive tumors found be more likely respond endocrine therapy associated better prognosis An understanding genetic changes involved its biologic behavior, possible interactions hormones oncogenes tumor suppressor genes, will undoubtedly aid design therapies as well prevention diagnosis this disease.