Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells

作者: Guen Tae Kim , Se Hee Lee , Young Min Kim

DOI: 10.15430/JCP.2013.18.3.264

关键词:

摘要: Background: The suppression of abnormal cell proliferation is therapeutic strategies for the treatment cancer. In this study, we investigated regulatory mechanism quercetin-induced apoptosis through regulation Sestrin 2 and AMPK signaling pathway.

参考文章(16)
Andrei V. Budanov, Michael Karin, p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling Cell. ,vol. 134, pp. 451- 460 ,(2008) , 10.1016/J.CELL.2008.06.028
Andrei V Budanov, Tzipora Shoshani, Alexander Faerman, Elena Zelin, Iris Kamer, Hagar Kalinski, Svetlana Gorodin, Alla Fishman, Ayelet Chajut, Paz Einat, Rami Skaliter, Andrei V Gudkov, Peter M Chrumakov, Elena Feinstein, Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability Oncogene. ,vol. 21, pp. 6017- 6031 ,(2002) , 10.1038/SJ.ONC.1205877
Su-Yu Chien, Yao-Chung Wu, Jing-Gung Chung, Jai-Sing Yang, Hsu-Feng Lu, Mei-Fen Tsou, WG Wood, Shou-Jen Kuo, Dar-Ren Chen, Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells. Human & Experimental Toxicology. ,vol. 28, pp. 493- 503 ,(2009) , 10.1177/0960327109107002
Arnold J Levine, p53, the Cellular Gatekeeper for Growth and Division Cell. ,vol. 88, pp. 323- 331 ,(1997) , 10.1016/S0092-8674(00)81871-1
Yun-Kyoung Lee, Jin-Taek Hwang, Dae Young Kwon, Young-Joon Surh, Ock Jin Park, Induction of apoptosis by quercetin is mediated through AMPKα1/ASK1/p38 pathway. Cancer Letters. ,vol. 292, pp. 228- 236 ,(2010) , 10.1016/J.CANLET.2009.12.005
Michelle Mouria, Anna S. Gukovskaya, Yoon Jung, Peter Buechler, Oscar J. Hines, Howard A. Reber, Stephen J. Pandol, Food‐derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis International Journal of Cancer. ,vol. 98, pp. 761- 769 ,(2002) , 10.1002/IJC.10202
Young-Min Kim, Won Sup Lee, Ock Jin Park, Yun-Kyoung Lee, Song Yi Park, AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin. Experimental and Molecular Medicine. ,vol. 41, pp. 201- 207 ,(2009) , 10.3858/EMM.2009.41.3.023
Z. Feng, H. Zhang, A. J. Levine, S. Jin, The coordinate regulation of the p53 and mTOR pathways in cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 8204- 8209 ,(2005) , 10.1073/PNAS.0502857102
Toran Sanli, Katja Linher-Melville, Theodoros Tsakiridis, Gurmit Singh, Sestrin2 Modulates AMPK Subunit Expression and Its Response to Ionizing Radiation in Breast Cancer Cells PLoS ONE. ,vol. 7, pp. e32035- ,(2012) , 10.1371/JOURNAL.PONE.0032035
Shunsuke TANIGAWA, Makoto FUJII, De-Xing HOU, Stabilization of p53 Is Involved in Quercetin-Induced Cell Cycle Arrest and Apoptosis in HepG2 Cells Bioscience, Biotechnology, and Biochemistry. ,vol. 72, pp. 797- 804 ,(2008) , 10.1271/BBB.70680