Effect of fexofenadine, a mast cell blocker, in infertile men with significantly increased testicular mast cells.

摘要: Aim: To investigate the role of fexofenadine, a mast cell blocker, on semen quality in treatment infertile men. Methods: The study included 16 Turkish idiopathic men with azoospermia or oligozoospermia who underwent testicular biopsy to examine cells containing tryptase. In all patients, complete medical history, clinical examination, analysis and serum hormone assay were carried out. specimens immunohistochemically stained antihuman tryptase for cells. number total per seminiferous tubule was calculated recorded as index. patients divided into two groups according their index: higher (≥1, n=9) lower (<1, n=7) index groups. Fexofenadine administered orally at dose 180 mg/day 4 9 months. Pre- post-treatment parameters, including motile sperm counts (TMC) compared. Spontaneous pregnancies after registered. Results: There no statistically significant difference TMC between pre-treatment values (P≥0.05). both groups, nobody had response there spontaneous pregnancy treatment. Conclusion: Although dysfunction is closely associated increased cells, appears not having any benefit increase