Kidney injury biomarkers during exposure to tenofovir-based pre-exposure prophylaxis

作者: Connie Celum , Jared M Baeten , Allan Ronald , Andrea D Branch , Renee Heffron

DOI: 10.1097/QAD.0000000000002865

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摘要: We previously reported a higher incidence of non-albumin proteinuria and small but significant decline in estimated glomerular filtration rate among HIV-negative adults randomized to emtricitabine/ tenofovir disoproxil fumarate pre-exposure prophylaxis (FTC/TDF PrEP) versus placebo. In nested case-control study participants FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between subjects who subsequently experienced one these endpoints randomly selected controls did not.

参考文章(9)
Thomas L. Nickolas, Kai M. Schmidt-Ott, Pietro Canetta, Catherine Forster, Eugenia Singer, Meghan Sise, Antje Elger, Omar Maarouf, David Antonio Sola-Del Valle, Matthew O'Rourke, Evan Sherman, Peter Lee, Abdallah Geara, Philip Imus, Achuta Guddati, Allison Polland, Wasiq Rahman, Saban Elitok, Nasir Malik, James Giglio, Suzanne El-Sayegh, Prasad Devarajan, Sudarshan Hebbar, Subodh J. Saggi, Barry Hahn, Ralph Kettritz, Friedrich C. Luft, Jonathan Barasch, Diagnostic and Prognostic Stratification in the Emergency Department Using Urinary Biomarkers of Nephron Damage Journal of the American College of Cardiology. ,vol. 59, pp. 246- 255 ,(2012) , 10.1016/J.JACC.2011.10.854
Rebecca Scherzer, Michelle Estrella, Yongmei Li, Andy I. Choi, Steven G. Deeks, Carl Grunfeld, Michael G. Shlipak, Association of tenofovir exposure with kidney disease risk in HIV infection AIDS. ,vol. 26, pp. 867- 875 ,(2012) , 10.1097/QAD.0B013E328351F68F
Marc M Solomon, Javier R Lama, David V Glidden, Kathleen Mulligan, Vanessa McMahan, Albert Y Liu, Juan Vicente Guanira, Valdilea G Veloso, Kenneth H Mayer, Suwat Chariyalertsak, Mauro Schechter, Linda-Gail Bekker, Esper Georges Kallás, David N Burns, Robert M Grant, iPrEx Study Team, None, Changes in renal function associated with oral emtricitabine/tenofovir disoproxil fumarate use for HIV pre-exposure prophylaxis. AIDS. ,vol. 28, pp. 851- 859 ,(2014) , 10.1097/QAD.0000000000000156
Kenneth K Mugwanya, Christina Wyatt, Connie Celum, Deborah Donnell, Nelly R Mugo, Jordan Tappero, James Kiarie, Allan Ronald, Jared M Baeten, Partners PrEP Study Team, None, Changes in glomerular kidney function among HIV-1-uninfected men and women receiving emtricitabine-tenofovir disoproxil fumarate preexposure prophylaxis: a randomized clinical trial. JAMA Internal Medicine. ,vol. 175, pp. 246- 254 ,(2015) , 10.1001/JAMAINTERNMED.2014.6786
Frédéric-Antoine Dauchy, Sylvie Lawson-Ayayi, Renaud de La Faille, Fabrice Bonnet, Claire Rigothier, Nadia Mehsen, Ghada Miremont-Salamé, Charles Cazanave, Carine Greib, Francois Dabis, Michel Dupon, Increased risk of abnormal proximal renal tubular function with HIV infection and antiretroviral therapy Kidney International. ,vol. 80, pp. 302- 309 ,(2011) , 10.1038/KI.2011.124
Amanda Mocroft, Ole Kirk, Peter Reiss, Stephane De Wit, Dalibor Sedlacek, Marek Beniowski, Jose Gatell, Andrew N Phillips, Bruno Ledergerber, Jens D Lundgren, EuroSIDA Study Group, None, Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients AIDS. ,vol. 24, pp. 1667- 1678 ,(2010) , 10.1097/QAD.0B013E328339FE53
Robert M Grant, Javier R Lama, Peter L Anderson, Vanessa McMahan, Albert Y Liu, Lorena Vargas, Pedro Goicochea, Martín Casapía, Juan Vicente Guanira-Carranza, Maria E Ramirez-Cardich, Orlando Montoya-Herrera, Telmo Fernández, Valdilea G Veloso, Susan P Buchbinder, Suwat Chariyalertsak, Mauro Schechter, Linda-Gail Bekker, Kenneth H Mayer, Esper Georges Kallás, K Rivet Amico, Kathleen Mulligan, Lane R Bushman, Robert J Hance, Carmela Ganoza, Patricia Defechereux, Brian Postle, Furong Wang, J Jeff McConnell, Jia-Hua Zheng, Jeanny Lee, James F Rooney, Howard S Jaffe, Ana I Martinez, David N Burns, David V Glidden, None, Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men The New England Journal of Medicine. ,vol. 363, pp. 2587- 2599 ,(2010) , 10.1056/NEJMOA1011205
Jared M Baeten, Deborah Donnell, Patrick Ndase, Nelly R Mugo, James D Campbell, Jonathan Wangisi, Jordan W Tappero, Elizabeth A Bukusi, Craig R Cohen, Elly Katabira, Allan Ronald, Elioda Tumwesigye, Edwin Were, Kenneth H Fife, James Kiarie, Carey Farquhar, Grace John-Stewart, Aloysious Kakia, Josephine Odoyo, Akasiima Mucunguzi, Edith Nakku-Joloba, Rogers Twesigye, Kenneth Ngure, Cosmas Apaka, Harrison Tamooh, Fridah Gabona, Andrew Mujugira, Dana Panteleeff, Katherine K Thomas, Lara Kidoguchi, Meighan Krows, Jennifer Revall, Susan Morrison, Harald Haugen, Mira Emmanuel-Ogier, Lisa Ondrejcek, Robert W Coombs, Lisa Frenkel, Craig Hendrix, Namandjé N Bumpus, David Bangsberg, Jessica E Haberer, Wendy S Stevens, Jairam R Lingappa, Connie Celum, None, Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. The New England Journal of Medicine. ,vol. 367, pp. 399- 410 ,(2012) , 10.1056/NEJMOA1108524
Kenneth Mugwanya, Jared Baeten, Connie Celum, Deborah Donnell, Thomas Nickolas, Nelly Mugo, Andrea Branch, Jordan Tappero, James Kiarie, Allan Ronald, Michael Yin, Christina Wyatt, Partners PrEP Study Team, Connie Celum, Jared M Baeten, Deborah Donnell, Robert W Coombs, Lisa Frenkel, Craig W Hendrix, Jairam R Lingappa, M Juliana McElrath, Eldoret Kenya, Kenneth H Fife, Edwin Were, Elioda Tumwesigye, Patrick Ndase, Elly Katabira, Allan Ronald, Elizabeth Bukusi, Craig R Cohen, Jonathan Wangisi, James D Campbell, Jordan W Tappero, James Kiarie, Carey Farquhar, Grace John-Stewart, Nelly R Mugo, James D Campbell, Jordan W Tappero, Jonathan Wangisi, None, Low Risk of Proximal Tubular Dysfunction Associated With Emtricitabine-Tenofovir Disoproxil Fumarate Preexposure Prophylaxis in Men and Women The Journal of Infectious Diseases. ,vol. 214, pp. 1050- 1057 ,(2016) , 10.1093/INFDIS/JIW125