作者: Connie Celum , Jared M Baeten , Allan Ronald , Andrea D Branch , Renee Heffron
DOI: 10.1097/QAD.0000000000002865
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摘要: We previously reported a higher incidence of non-albumin proteinuria and small but significant decline in estimated glomerular filtration rate among HIV-negative adults randomized to emtricitabine/ tenofovir disoproxil fumarate pre-exposure prophylaxis (FTC/TDF PrEP) versus placebo. In nested case-control study participants FTC/TDF PrEP, established kidney injury biomarkers measured at 12 months were not significantly different between subjects who subsequently experienced one these endpoints randomly selected controls did not.