The Effect of Psilocin on Memory Acquisition, Retrieval, and Consolidation in the Rat

摘要: The involvement of the serotonin system in pathophysiology schizophrenia has been elucidated by experiments with hallucinogens. Application a hallucinogen to humans leads changes perception, cognition, emotions and induction psychotic-like symptoms that resemble schizophrenia. In rodent studies, their acute administration affects sensorimotor gating, locomotor activity, social behavior cognition including working memory, phenotypes are considered as an animal model complexity singularity human raises questions about validity models utilizing agonists 5-HT2A receptors. present study thus investigated effect psilocin on memory acquisition, reinforced retrieval consolidation rats. Psilocin is main metabolite psilocybin acting agonist at receptors contribution 5-HT2C 5-HT1A First, we tested acquisition Carousel maze, spatial task requiring navigation using distal cues, attention cognitive coordination. significantly impaired Maze both doses (1 4 mg/kg). higher dose blocked learning processes even additional session when rats received only saline. Next, examined Morris water maze (MWM). mg/kg disrupted maze. However, application lower was without any significant effect. Finally, neither low nor high injected post-training caused deficit MWM. Taken together, dependently MWM; however, it had no consolidation.