Serotonergic drug effects on a delayed conditional discrimination task in the rat; involvement of the 5-HT1A receptor in working memory.
作者： Arnoud H. J. Herremans , Theo H. Hijzen , Berend Olivier , Jef L. Slangen
DOI: 10.1177/026988119500900307
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摘要: We investigated the effects of serotonergic drugs on working memory (WM) in a delayed conditional discrimination task. The 5-HT1A receptor full agonist flesinoxan (0.3-3.0 mg/kg) dose- and delay-dependently impaired performance, indicating specific effect WM. partial ipsapirone, 5-HT 1B/1D/2C TFMPP, antagonist NAN190 serotonin re-uptake inhibitor fluvoxamine dose-dependently delay-independent manner, no 2 ketanserin 5-HT3 ondansetron did not affect performance. It is suggested that role central receptors WM may be restricted to receptors.
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