The 5-HT1A receptor antagonist WAY 100635 improves rats performance in different models of amnesia evaluated by the object recognition task
作者： Nikolaos Pitsikas , Antonello E. Rigamonti , Silvano G. Cella , Eugenio E. Muller
DOI: 10.1016/S0006-8993(03)03091-9
关键词: Cognitive neuroscience of visual object recognition 、 Cognition 、 Extinction (psychology) 、 Serotonergic 、 5-HT1A receptor 、 Psychology 、 Antagonist 、 Amnesia 、 Recognition memory 、 Neuroscience
摘要: Abstract The effects of the 5-HT 1A receptor antagonist WAY 100635 on recognition memory were investigated in two different amnestic models rat by using object task. at 1 mg/kg, but not 0.3 counteracted scopolamine-induced performance deficits acquisition version this behavioral paradigm. At same dose, antagonized extinction normal rat, suggesting that it affected acquisition, storage and retrieval information. These results support extend prior findings interactions between serotonergic cholinergic systems are relevant to cognition indicate modulates aspects memory.
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sci-hub.se 参考文章(30)
Bruce Hunter, Steven F. Zornetzer, Murray E. Jarvik, James L. McGaugh, Modulation of Learning and Memory: Effects of Drugs Influencing Neurotransmitters Springer, Boston, MA. pp. 531- 577 ,(1977) , 10.1007/978-1-4684-3180-3_11
Stephen J. Peroutka, Serotonin receptor subtypes : basic and clinical aspects Wiley-Liss. ,(1991)
Allan Fletcher, Elaine A. Forster, David J. Bill, Geraldine Brown, Ian A. Cliffe, Jane E. Hartley, Deborah E. Jones, Anne McLenachan, Kelly J. Stanhope, David J.P. Critchley, Kirstie J. Childs, Vicki C. Middlefell, Laurence Lanfumey, Renato Corradetti, Anne-Marie Laporte, Henri Gozlan, Michel Hamon, Colin T. Dourish, Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist. Behavioural Brain Research. ,vol. 73, pp. 337- 353 ,(1995) , 10.1016/0166-4328(96)00118-0
Clementina Bianchi, Anna Siniscalchi, Lorenzo Beani, 5-HT1A agonists increase and 5-HT3 agonists decrease acetylcholine efflux from the cerebral cortex of freely-moving guinea-pigs. British Journal of Pharmacology. ,vol. 101, pp. 448- 452 ,(1990) , 10.1111/J.1476-5381.1990.TB12728.X
Takako Koyama, Yasuo Nakajima, Takeshi Fujii, Koichiro Kawashima, Enhancement of cortical and hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by BAY×3702 in freely moving rats Neuroscience Letters. ,vol. 265, pp. 33- 36 ,(1999) , 10.1016/S0304-3940(99)00200-1
T Steckler, W.H.I.M Drinkenburg, A Sahgal, J.P Aggleton, Recognition memory in rats-I. Concepts and classification Progress in Neurobiology. ,vol. 54, pp. 289- 311 ,(1998) , 10.1016/S0301-0082(97)00060-9
Arnoud H. J. Herremans, Theo H. Hijzen, Berend Olivier, Jef L. Slangen, Serotonergic drug effects on a delayed conditional discrimination task in the rat; involvement of the 5-HT1A receptor in working memory. Journal of Psychopharmacology. ,vol. 9, pp. 242- 250 ,(1995) , 10.1177/026988119500900307
Albert Cavoy, Jean Delacour, Spatial but not object recognition is impaired by aging in rats Physiology & Behavior. ,vol. 53, pp. 527- 530 ,(1993) , 10.1016/0031-9384(93)90148-9
Silvana Consolo, Simona Ramponi, Herbert Ladinsky, Gianni Baldi, A critical role for D1 receptors in the 5-HT1A-mediated facilitation of in vivo acetylcholine release in rat frontal cortex Brain Research. ,vol. 707, pp. 320- 323 ,(1996) , 10.1016/0006-8993(95)01369-5
Mirjana Carli, Pierenrico Bonalumi, Rosario Samanin, WAY 100635, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal administration of scopolamine or 7-chloro-kynurenic acid. Brain Research. ,vol. 774, pp. 167- 174 ,(1997) , 10.1016/S0006-8993(97)81700-3