The growth and metastasis of human, HER-2/neu-overexpressing tumor cell lines in male SCID mice.
作者： Birgitta Clinchy , Adi Gazdar , Rosalia Rabinovsky , Eitan Yefenof , Brian Gordon
关键词:
摘要: HER-2/neu is overexpressed on a variety of human adenocarcinomas and overexpression has been associated with poor prognosis. For this reason, HER-2 become an attractive target for immunotherapy. To facilitate testing anti-HER-2-monoclonal antibodies (MAbs) immunotoxins (ITs), we have evaluated the in vivo growth metastatic spread three HER-2-overexpressing breast cancer cell lines (BT474, MDA-MB-453 HCC1954) one ovarian line (SKOV3.ip1) pre-irradiated male SCID mice using subcutaneous (s.c.), intravenous (i.v.) intraperitoneal (i.p.) routes injection. All tested grew as s.c. tumors BT474 cells after injection was improved by co-inoculation Matrigel. Metastases to lungs were detectable PCR or histopathology much lesser extent HCC1954, MD-MB-453 SKOV3.ip1cells. I.P. HCC1954 SKOV3.ip1 produced fatal ascites while i.v. SKOV3.ip1, but not cells, resulted infiltration death within 9–11 weeks.
springer.com
elsevier.com
researchgate.net 
utsystem.edu 参考文章(52)
Carlos Cordon-Cardo, Michael F. Press, Dennis J. Slamon, Expression of the HER-2/neu proto-oncogene in normal human adult and fetal tissues. Oncogene. ,vol. 5, pp. 953- 962 ,(1990)
R. D. Zhang, I. J. Fidler, J. E. Price, Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion & Metastasis. ,vol. 11, pp. 204- 215 ,(1991)
S Visonneau, E J Miller, A Cesano, D Santoli, M H Torosian, Growth characteristics and metastatic properties of human breast cancer xenografts in immunodeficient mice. American Journal of Pathology. ,vol. 152, pp. 1299- 1311 ,(1998)
M D Pegram, R J Pietras, S B Howell, V R Chazin, B M Fendly, D J Slamon, Antibody to HER-2/neu receptor blocks DNA repair after cisplatin in human breast and ovarian cancer cells. Oncogene. ,vol. 9, pp. 1829- 1838 ,(1994)
J R Zabrecky, T Lam, S J McKenzie, W Carney, The extracellular domain of p185/neu is released from the surface of human breast carcinoma cells, SK-BR-3. Journal of Biological Chemistry. ,vol. 266, pp. 1716- 1720 ,(1991) , 10.1016/S0021-9258(18)52354-1
Zalutsky Mr, Eccles Sa, Dean Cj, Carnochan P, Garg Pk, Sacks Np, Smellie Wj, Radioimmunotherapy of Breast Cancer Xenografts with Monoclonal Antibody ICR12 against c-erbB2 p185: Comparison of Iodogen and N-Succinimidyl 4-Methyl-3-(tri-n-butylstannyl)benzoate Radioiodination Methods Cancer Research. ,vol. 55, ,(1995)
Mary L. Disis, Martin A. Cheever, HER-2/neu protein: a target for antigen-specific immunotherapy of human cancer. Advances in Cancer Research. ,vol. 71, pp. 343- 371 ,(1997) , 10.1016/S0065-230X(08)60103-7
Alphonse Taghian, Wilfried Budach, Anthony Zietman, Jill Freeman, Danielle Gioioso, Wlodzimierz Ruka, Herman D Suit, Quantitative Comparison between the Transplantability of Human and Murine Tumors into the Subcutaneous Tissue of NCr/Sed-nu/nu Nude and Severe Combined Immunodeficient Mice Cancer Research. ,vol. 53, pp. 5012- 5017 ,(1993)
H Sonoo, H Saito, R B Dickson, H Fukumori, J Kurebayashi, N Unemi, M Nukatsuka, M Kurosumi, S Takeda, A Fujioka, Postsurgical oral administration of uracil and tegafur inhibits progression of micrometastasis of human breast cancer cells in nude mice. Clinical Cancer Research. ,vol. 3, pp. 653- 659 ,(1997)
János Szöllösi, Margit Balázs, Burt G Feuerstein, Christopher C Benz, Frederic M Waldman, None, ERBB-2 (HER2/neu) Gene Copy Number, p185HER-2 Overexpression, and Intratumor Heterogeneity in Human Breast Cancer Cancer Research. ,vol. 55, pp. 5400- 5407 ,(1995)