Long-term administration of prolactin or testosterone induced similar precancerous prostate lesions in rats.

摘要: Evidence indicates that prolactin plays a crucial role in the normal function and development of prostate, but abnormal high levels hormone are associated with hyperplasia cancer gland. Aims: The present study was designed to describe progressive specific histological abnormalities prostate rats chronic hyperprolactinemia. Material Methods: Prolactin administered during 4; 12 or 24 weeks, resulting prostatic alterations were compared control rats, also those treated testosterone, combination + testosterone. Results: Rats prolactin, testosterone expressed precancerous dorsolateral ventral portions as early 4 weeks treatment, all cases malignancy increased after treatment.