Vitamin D receptor gene polymorphisms and colorectal cancer risk: A systematic meta-analysis
作者： Yong-Heng Bai , Hong Lu , Dan Hong , Cheng-Cheng Lin , Zhen Yu
关键词:
摘要: AIM: To investigate the relationship between polymorphisms present in vitamin D receptor (VDR) gene and colorectal cancer risk, a systematic meta-analysis of population-based studies was performed. METHODS: A total 38 relevant reports published January 1990 August 2010 were identified, which only 23 qualified for this based on our selection criteria. Five polymorphic variants VDR gene, including Cdx-2 (intron 1e) FokI (exon 2) 5’ region BsmI 8), ApaI TaqI 9) sites 3’ untranslated (UTR), evaluated possible associations with risk. Review manager 4.2 used to perform statistical analyses. RESULTS: In performed, polymorphism found be associated particular, B genotype related an overall decrease risk [BB vs bb: odds ratio (OR) = 0.87, 95% CI: 0.80-0.94, P 3 × 10-4; BB Bb + OR 0.90, 0.84-0.97, 5 10-4]. Moreover, subgroup analyses, significantly colon cancer, not rectal cancer. An absence between-study heterogeneity also observed. CONCLUSION: identified increased
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