How B-Cell Receptor Repertoire Sequencing Can Be Enriched with Structural Antibody Data.

摘要: Next-generation sequencing of immunoglobulin gene repertoires (Ig-seq) allows the investigation large-scale antibody dynamics at a sequence level. However, structural information, crucial descriptor binding capability, is not collected in Ig-seq protocols. Developing systematic relationships between information gathered from and low-throughput techniques such as X-ray crystallography could radically improve our understanding antibodies. The mapping datasets to known structures can indicate structurally, perhaps functionally, uncharted areas. Furthermore, contrasting naive antigenically challenged using descriptors should provide insights into maturation. As number steadily increases more become available, opportunities that arise combining two types increase well. Here, we review how these data enrich one another show potential for advancing knowledge immune system improving engineering.