Methods for detecting and reducing impurities of Lapatinib and salts thereof
作者： Alessandro Leganza , Francesco Fontana , Sergio Osti
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摘要: Impurities of lapatinib such as N-{3-chloro-4-[(2-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)furan-2-yl]quinazoline-4-amine compound formula (I) or a salt thereof: and analytical methods for identifying quantifying impurities Lapatinib salts thereof are provided. Also provided is containing less than about 0.05 percent this related preparing pure forms Lapatinib.
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