Quantifying the role of burn temperature, burn duration and skin thickness in an in vivo animal skin model of heat conduction

摘要: To determine the extent to which heat conduction through skin is affected by thickness, burn temperature, and duration, we perform a suite of experiments using an in vivo porcine (pig) model. Fourteen different conditions are considered, each condition replicated at least four times, giving total sixty individual experimental burns. The subdermal temperature within recorded as function time during experiment. quantitatively interpret data, develop exact solution simplified, depth-averaged, equation. Calibrating this data provide estimates effective thermal diffusivity skin, $\alpha$, loss rate, $k$. Estimates $\alpha$ $k$ obtained for fourteen different, clinically relevant, conditions. Overall, find $\alpha = 0.03 \pm 0.02$ mm2/s (to one significant figure), approximately independent $H$. This estimate implies that required energy diffuse vertically down, thicker ($H 2.27$ mm) thinner 1.40$ skinned animals 170 70 s, respectively. We $k 0.002 0.002$ /s figure). In summary, our results contemporary properties has broad application transfer modelling investigations injury prevention therapy studies.