Lower active force generation and improved fatigue resistance in skeletal muscle from desmin deficient mice.
作者： J. Balogh , Z. Li , D. Paulin , A. Arner
关键词:
摘要: The mechanical effects of the intermediate filament protein desmin was examined in deficient mice (Des-/-) and their wild type control (Des+/+). Active force generation determined intact soleus muscles skinned single fibres from psoas. A decreased muscle Des-/- a tendency towards active were detected. Concentrations contractile actin myosin not altered muscles. Ca(2+)-sensitivity unchanged compared to Des+/+. Using protocol with repeated short tetani an increased fatigue resistance found mice. In conclusion, filaments are required for optimal or transmission skeletal muscle. Although other studies have shown that appear influence Ca(2+)-handling, is Previous reported switch slower isoforms slow show this change reflected physiological function
springer.com
sci-hub.se 参考文章(33)
E Lazarides, Intermediate Filaments: A Chemically Heterogeneous, Developmentally Regulated Class of Proteins Annual Review of Biochemistry. ,vol. 51, pp. 219- 250 ,(1982) , 10.1146/ANNUREV.BI.51.070182.001251
G. Sjoberg, C. A. Saavedra-Matiz, D. R. Rosen, E. M. Wijsman, K. Borg, S. H. Horowitz, T. Sejersen, A Missense Mutation in the Desmin Rod Domain Is Associated with Autosomal Dominant Distal Myopathy, and Exerts a Dominant Negative Effect on Filament Formation Human Molecular Genetics. ,vol. 8, pp. 2191- 2198 ,(1999) , 10.1093/HMG/8.12.2191
Zhenlin Li, Mathias Mericskay, Onnik Agbulut, Gillian Butler-Browne, Lena Carlsson, Lars-Eric Thornell, Charles Babinet, Denise Paulin, Desmin Is Essential for the Tensile Strength and Integrity of Myofibrils but Not for Myogenic Commitment, Differentiation, and Fusion of Skeletal Muscle Journal of Cell Biology. ,vol. 139, pp. 129- 144 ,(1997) , 10.1083/JCB.139.1.129
L.-E. Thornell, L. Carlsson, Z. Li, M. Mericskay, D. Paulin, Null mutation in the desmin gene gives rise to a cardiomyopathy. Journal of Molecular and Cellular Cardiology. ,vol. 29, pp. 2107- 2124 ,(1997) , 10.1006/JMCC.1997.0446
Laurence Kay, Zhenlin Li, Mathias Mericskay, Jose Olivares, Leone Tranqui, Eric Fontaine, Toomas Tiivel, Peeter Sikk, Tuuli Kaambre, Jeane-Lyze Samuel, Lydie Rappaport, Yves Usson, Xavier Leverve, Denise Paulin, Valdur A Saks, Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochimica et Biophysica Acta. ,vol. 1322, pp. 41- 59 ,(1997) , 10.1016/S0005-2728(97)00071-6
Aladin M. Boriek, Y. Capetanaki, Willy Hwang, Todd Officer, Muffasir Badshah, Joe Rodarte, James G. Tidball, Desmin integrates the three-dimensional mechanical properties of muscles American Journal of Physiology-cell Physiology. ,vol. 280, ,(2001) , 10.1152/AJPCELL.2001.280.1.C46
R. SJUVE, A. ARNER, Z. LI, B. MIES, D. PAULIN, M. SCHMITTNER, J. V. SMALL, Mechanical alterations in smooth muscle from mice lacking desmin. Journal of Muscle Research and Cell Motility. ,vol. 19, pp. 415- 429 ,(1998) , 10.1023/A:1005353805699
Fabiato A, Fabiato F, Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. Journal de physiologie. ,vol. 75, pp. 463- 505 ,(1979)
Lev G. Goldfarb, Kye-Yoon Park, Larisa Cervenáková, Svetlana Gorokhova, Hee-Suk Lee, Olavo Vasconcelos, James W. Nagle, Christina Semino-Mora, Kumaraswamy Sivakumar, Marinos C. Dalakas, Missense mutations in desmin associated with familial cardiac and skeletal myopathy Nature Genetics. ,vol. 19, pp. 402- 403 ,(1998) , 10.1038/1300
L. E. Thornell, A. Eriksson, Filament systems in the Purkinje fibers of the heart. American Journal of Physiology-heart and Circulatory Physiology. ,vol. 241, ,(1981) , 10.1152/AJPHEART.1981.241.3.H291