Physicochemical properties and Mycobacterium tuberculosis transporters: keys to efficacious antitubercular drugs?

摘要: Securing novel, safe, and effective medicines to treat Mycobacterium tuberculosis remains an elusive goal, particularly influenced by the largely impervious Mtb envelope that limits exposure thus efficacy of inhibitors at their cellular periplasmic targets. The impact physicochemical properties on pharmacokinetic parameters govern oral absorption sites infection is considered alongside how these influence penetration envelope, with likely transporter proteins. findings are discussed benchmark current drugs emerging pipeline, whilst considering tactics for future rational targeted design strategies, based around data transporters structures functions.